Persistent sad, anxious, or “empty” mood

Feelings of hopelessness, pessimism

Feelings of guilt, worthlessness, helplessness

Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex

Decreased energy, fatigue, being “slowed down”

Difficulty concentrating, remembering, making decisions

Trouble sleeping, early-morning awakening, or oversleeping

Appetite and/or weight changes

Thoughts of death or suicide, or suicide attempts

Restlessness, irritability

Persistent physical symptoms, such as headaches, digestive disorders, and chronic pain, which do not respond to routine treatment.