Pantethine and pantothenic acid are safe to take with most medications. Tricyclic antidepressant medications (imipramine, despramine, and other psychotropic medications) have been known to interact with pantethine supplements. Check with your doctor if you are taking these medications. Also, if you are presently on steroidal drug therapy, do not take pantethine instead of your steroids. It is indicated only after having discontinued with your steroid regimen. The effects of the medication levodopa may be decreased by supplemental pantothenic acid. This problem is not seen with combination carbidopa and levodopa products. These medications are often used to treat symptoms of Parkinson's disease. Anyone taking medication for this condition should consult a health care provider before taking nutritional supplements.